Predictors of dementia in Parkinson disease
Identifieur interne : 000965 ( Main/Exploration ); précédent : 000964; suivant : 000966Predictors of dementia in Parkinson disease
Auteurs : Julius B. M. Anang ; Jean-Francois Gagnon ; Josie-Anne Bertrand ; Silvia Rios Romenets ; Veronique Latreille ; Michel Panisset ; Jacques Montplaisir ; Ronald B. PostumaSource :
- Neurology [ 0028-3878 ] ; 2014.
English descriptors
- KwdEn :
- Age Factors, Aged, Blood Pressure, Cognitive Dysfunction (epidemiology), Cognitive Dysfunction (etiology), Color Vision Defects (epidemiology), Dementia (epidemiology), Dementia (etiology), Female, Follow-Up Studies, Gait, Humans, Logistic Models, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (epidemiology), Prospective Studies, REM Sleep Behavior Disorder (epidemiology), Risk Factors, Sex Factors, Time Factors.
- MESH :
- complications : Parkinson Disease.
- epidemiology : Cognitive Dysfunction, Color Vision Defects, Dementia, Parkinson Disease, REM Sleep Behavior Disorder.
- etiology : Cognitive Dysfunction, Dementia.
- Age Factors, Aged, Blood Pressure, Female, Follow-Up Studies, Gait, Humans, Logistic Models, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Time Factors.
Abstract
We investigated an array of possible markers of early dementia in Parkinson disease.
We performed a comprehensive assessment of autonomic, sleep, psychiatric, visual, olfactory, and motor manifestations in 80 patients with Parkinson disease who were dementia-free at baseline. After 4.4 years’ follow-up, patients were evaluated for dementia. Predictive variables were assessed using logistic regression adjusting for disease duration, follow-up duration, age, and sex.
Of 80 patients, 27 (34%) developed dementia. Patients destined to develop dementia were older and more often male (odds ratio [OR] = 3.64,
Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.
Url:
DOI: 10.1212/WNL.0000000000000842
PubMed: 25171928
PubMed Central: 4180482
Affiliations:
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Le document en format XML
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<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
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<author><name sortKey="Bertrand, Josie Anne" sort="Bertrand, Josie Anne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name>
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<author><name sortKey="Romenets, Silvia Rios" sort="Romenets, Silvia Rios" uniqKey="Romenets S" first="Silvia Rios" last="Romenets">Silvia Rios Romenets</name>
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<author><name sortKey="Latreille, Veronique" sort="Latreille, Veronique" uniqKey="Latreille V" first="Veronique" last="Latreille">Veronique Latreille</name>
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<author><name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name>
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<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
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<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
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<author><name sortKey="Romenets, Silvia Rios" sort="Romenets, Silvia Rios" uniqKey="Romenets S" first="Silvia Rios" last="Romenets">Silvia Rios Romenets</name>
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<author><name sortKey="Latreille, Veronique" sort="Latreille, Veronique" uniqKey="Latreille V" first="Veronique" last="Latreille">Veronique Latreille</name>
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<author><name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name>
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<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
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<author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
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<series><title level="j">Neurology</title>
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<term>Cognitive Dysfunction (etiology)</term>
<term>Color Vision Defects (epidemiology)</term>
<term>Dementia (epidemiology)</term>
<term>Dementia (etiology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Gait</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Prospective Studies</term>
<term>REM Sleep Behavior Disorder (epidemiology)</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Time Factors</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognitive Dysfunction</term>
<term>Color Vision Defects</term>
<term>Dementia</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognitive Dysfunction</term>
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<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Blood Pressure</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Gait</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Risk Factors</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>We investigated an array of possible markers of early dementia in Parkinson disease.</p>
</sec>
<sec><title>Methods:</title>
<p>We performed a comprehensive assessment of autonomic, sleep, psychiatric, visual, olfactory, and motor manifestations in 80 patients with Parkinson disease who were dementia-free at baseline. After 4.4 years’ follow-up, patients were evaluated for dementia. Predictive variables were assessed using logistic regression adjusting for disease duration, follow-up duration, age, and sex.</p>
</sec>
<sec><title>Results:</title>
<p>Of 80 patients, 27 (34%) developed dementia. Patients destined to develop dementia were older and more often male (odds ratio [OR] = 3.64, <italic>p</italic>
= 0.023). Those with baseline mild cognitive impairment had increased dementia risk (OR = 22.5, <italic>p</italic>
< 0.001). REM sleep behavior disorder at baseline dramatically increased dementia risk (OR = 49.7, <italic>p</italic>
= 0.001); however, neither daytime sleepiness nor insomnia predicted dementia. Higher baseline blood pressure increased dementia risk (OR = 1.37 per 10 mm Hg, <italic>p</italic>
= 0.032). Orthostatic blood pressure drop was strongly associated with dementia risk (OR = 1.84 per 10 mm Hg, <italic>p</italic>
< 0.001); having a systolic drop of >10 mm Hg increased dementia odds 7-fold (OR = 7.3, <italic>p</italic>
= 0.002). Abnormal color vision increased dementia risk (OR = 3.3, <italic>p</italic>
= 0.014), but olfactory dysfunction did not. Among baseline motor variables, proportion of gait involvement (OR = 1.12, <italic>p</italic>
= 0.023), falls (OR = 3.02, <italic>p</italic>
= 0.042), and freezing (OR = 2.63, <italic>p</italic>
= 0.013), as well as the Purdue Pegboard Test (OR = 0.67, <italic>p</italic>
= 0.049) and alternate tap test (OR = 0.97, <italic>p</italic>
= 0.033) predicted dementia.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.</p>
</sec>
</div>
</front>
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<tree><noCountry><name sortKey="Anang, Julius B M" sort="Anang, Julius B M" uniqKey="Anang J" first="Julius B. M." last="Anang">Julius B. M. Anang</name>
<name sortKey="Bertrand, Josie Anne" sort="Bertrand, Josie Anne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name>
<name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
<name sortKey="Latreille, Veronique" sort="Latreille, Veronique" uniqKey="Latreille V" first="Veronique" last="Latreille">Veronique Latreille</name>
<name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name>
<name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
<name sortKey="Romenets, Silvia Rios" sort="Romenets, Silvia Rios" uniqKey="Romenets S" first="Silvia Rios" last="Romenets">Silvia Rios Romenets</name>
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